Aug 03, 2022
In Medical Forum
Based on this, my country has also formulated the tolerance standard for residues of lecithin: 0.04ppm for kidney and liver, 0.01ppm for pork, fat and other parts (0.01ppm). = 10 μg/Kg); converted to 60 kg of adults, each person may eat 6 kg of pork, 1.5 kg of liver or kidneys per day to exceed the standard. And as mentioned above, the MRL is set with reference to the Chinese food intake database, and the daily "total exposure" is actually much lower than the ADI. Therefore, even if it exceeds the standard, it is still different from poisoning, which only means that it is not accepted by legal standards. , manufacturers exceeding the standard will be subject to administrative penalties. Xu Huitai, Professor, Vice Dean and Head of the Department of Public Health, China Medical popular database University November 26, 2021 In addition to being called clenbuterol, ractopamine (Ractopamine, hereinafter referred to as Lai) actually has another name, called Beta-adrenergic agonist. The main meaning is that when ractopamine enters the body, it will bind to the beta receptor in the body and have an effect. There are three locations of beta receptors in the body, the first is in the heart tissue, when beta sympathetic receptor agonists bind to beta receptors here, it will promote the heartbeat. The second is the smooth muscle in the trachea of the lungs, which promotes the expansion of the trachea, so there was a drug manufacturer who wanted to use lysine as a drug for asthma. The third is in adipose tissue, which promotes fat metabolism. It is also used to feed cattle or pigs to reduce fat and increase the amount of lean meat, so it is called clenbuterol. Under such a basic understanding, the impact of exposure to lysine is a heart problem. Therefore, in JECFA's 6-person exposure experiment, the observed negative effects are cardiac parameters. In this experiment, subjects were given 67, 133, 200, 333, and 597 micrograms/kg of ractopamine orally, and it was found that at the dose of 67 micrograms/kg, the subjects did not observe negative effects on cardiac parameters. Therefore, it becomes the basis for assessing the exposed daily dose. In the process of estimating the acceptable exposure dose for humans, considering that the participants in the experiment were healthy adults, in order to protect sensitive groups, 67 μg/kg was divided by 10 to reduce the daily exposure dose; The experiment was only a 6-person experiment, and the sample was small, so a safety factor of 5 was put in. So, 67/(5×10) = 1.34 micrograms/kg. Finally, remove the suffix 0.34 to get the maximum safe daily intake of 1.0 micrograms/kg. That is, each of us can be exposed to 1.0 micrograms of lysine per kilogram of body weight per day. In other words, a person weighing 60 kg can be exposed to 60 micrograms of lysine a day.